At physiological levels, ROS play an essential role in redox signaling by influencing the activity of transcription factors such as NF-B and Nrf2, and modulating pathways like MAPK and PI3K/Akt, which are vital for neuronal survival and adaptation (Finkel and Holbrook, 2000
Figure 3 (b) Glycolysis pathway, demonstrating niacins (B3) role in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, and its links to both the Pentose Phosphate Pathway and the Krebs Cycle ( (c) Krebs Cycle, illustrating its connection to glycolysis, Electron Transport Chain, and Fatty Acid Beta-Oxidation pathway
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These results indicate that pyridoxine can reduce the severity of dopaminergic neuron loss when administered before MPTP beyond targeting dopamine receptors
